Retention of an appropriate astrocytic response to retinoids by human brain tumors composed of predominantly glial fibrillary acidic protein-positive cells
نویسندگان
چکیده
منابع مشابه
Genetic Background Affects Human Glial Fibrillary Acidic Protein Promoter Activity
The human glial fibrillary acidic protein (hGFAP) promoter has been used to generate numerous transgenic mouse lines, which has facilitated the analysis of astrocyte function in health and disease. Here, we evaluated the expression levels of various hGFAP transgenes at different ages in the two most commonly used inbred mouse strains, FVB/N (FVB) and C57BL/6N (B6N). In general, transgenic mice ...
متن کاملFibronectin and glial fibrillary acidic protein expression in normal human brain and anaplastic human gliomas.
The expression of fibronectin (FN), an extracellular matrix glycoprotein with adhesive and opsonic properties, was ex amined in normal and neoplastia human central nervous system tissues. In both normal adult and fetal brain, FN expression, as detected by ¡mmunohistochemistry, was restricted to the vasculature. Neurons and glia did not stain. FN expression in nine of 10 gliomas examined was qu...
متن کاملCortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injury.
Glial fibrillary acidic protein-positive (GFAP(+)) cells give rise to new neurons in the neurogenic niches; whether they are able to generate neurons in the cortical parenchyma is not known. Here, we use genetic fate mapping to examine the progeny of GFAP(+) cells after postnatal hypoxia, a model for the brain injury observed in premature children. After hypoxia, immature cortical astroglia und...
متن کاملAging results in copper accumulations in glial fibrillary acidic protein-positive cells in the subventricular zone.
Analysis of rodent brains with X-ray fluorescence (XRF) microscopy combined with immunohistochemistry allowed us to demonstrate that local Cu concentrations are thousands of times higher in the glia of the subventricular zone (SVZ) than in other cells. Using XRF microscopy with subcellular resolution and intracellular X-ray absorption spectroscopy we determined the copper (I) oxidation state an...
متن کاملAcidic Protein Complementary DNA: Analysis of Expression, Transfection of Human Astrocytoma Cells with Glial Fibrillary
Glial fibrillary acidic protein (GFAP) is a A/, 50,000 intracytoplasmic filamentous protein that constitutes a portion of, and is spécifiefor the cytoskeleton of the astrocyte. GFAP appears to stabilize the astrocyte's cytoskeleton, and helps maintain normal astrocyte cell shape through complex interactions between it and the nuclear and plasma membranes. A critical observation from histopatho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neurosurgical Focus
سال: 1998
ISSN: 1092-0684
DOI: 10.3171/foc.1998.4.4.5